Allergy and Inflammation

Molecular Hydrogen Research on Allergy and Inflammation

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis 
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the population. It is characterized by destruction of bone and cartilage. The harmful free radical hydroxyl radical has been suggested to contribute to RA. Molecular hydrogen selectively neutralizes hydroxyl radicals. This study suggests that molecular hydrogen saturated water may be useful to complement conventional RA therapy by reducing oxidative stress.

Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model
Multiple organ dysfunction syndrome (MODS) is the leading cause of death in critically ill patients. MODS is defined as the progressive deterioration of function of several organs or organ systems in patients with severe sepsis, septic shock, multiple trauma, severe burns, pancreatitis and so on. Many animal and human studies have found that excessive reactive oxygen species (ROS) production play an important role in the pathogenesis of MODS. Since molecular hydrogen (H2) exerts a therapeutic antioxidant activity, this study aims to prove its beneficial effect on MODS. Zymosan is a chemical solution that induces generalized inflammation which is similar to the pathogenesis of MODS. Notable findings from this study include:
  • H2 prevented abnormal changes of oxidant and antioxidant systems in ZY-challenged mice.
  • H2 improved survival rate in ZY-challenged mice.
  • H2 treatment reduced the levels of early and late inflammatory cytokines in ZY-challenged mice.
Overall, this study confirmed that H2 can be used as a therapeutic agent in the treatment of conditions associated with inflammation and MODS.

Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast cells
Immediate-type allergies are not necessarily caused by oxidative stress, and the effects of molecular hydrogen for allergies have not been reported to date. In this study, the preventive effects of molecular hydrogen for type I allergic reaction was confirmed in a mouse model. Molecular hydrogen treatment significantly reduced the release of b-hexosaminidase, a marker of degranulation, indicating that degranulation was suppressed by molecular hydrogen. Molecular hydrogen also mediated NADPH oxidase activity in mast cells. Furthermore, inhibition of NADPH oxidase by molecular hydrogen resulted in suppression of FceRI-mediated signal transduction in mast cells. Hydrogen attenuated type I allergy in mice through suppression of the FceRI-mediated signal transduction. Our studies suggest that hydrogen may be effective for a wide variety of allergic diseases such as bronchial asthma, rhinitis, conjunctivitis, pollinosis and urticaria in humans, due to its capacity to modulate signal transduction.
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