Molecular Hydrogen Research on Cancer

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
A randomized, placebo controlled study showed that patients receiving radiotherapy for liver tumors who were drinking molecular hydrogen water had lower ROS (Reactive Oxygen Species) metabolites and higher QOL (Quality of Life) scores than patients who drank placebo water during treatment. This shows that molecular hydrogen may be a powerful adjunct to conventional cancer therapies.

Hydrogen protects mice from radiation induced thymic lymphoma
Ionizing radiation is a carcinogen that promotes tumor formation and progression inside human tissues. This study used ionizing radiation to induce lymphoma in mice, and treated the mice using molecular hydrogen rich saline. It was found that molecular hydrogen treatment significantly increased the survival rate of mice, by decreasing the reactive oxygen species (ROS) produced in the cells by ionizing radiation.

Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis
It has been reported that cancer cells produce high amounts of ROS, including H2O2 (Hydrogen Peroxide). Angiogenesis is an important factor in tumor growth. If angiogenesis of a tumor is halted, it leads to the necrosis of the tumor. Angiogenesis is regulated by VEGF, which has a connection to H2O2. Molecular Hydrogen is known to be an effective antioxidant that can stimulate the action of endogenous antioxidant enzymes. This study showed that molecular hydrogen helped decrease H2O2 formation in the cells, thereby reducing angiogenesis proliferation.

Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
Cisplatin is a widely used cancer drug in the treatment of a wide range of tumors. However, cisplatin is nephrotoxic due to its tendency to cause oxidative stress. Since molecular hydrogen acts as an efficient antioxidant, we want to show that molecular hydrogen can effectively minimize the nephrotoxicity and other side effects of cisplatin. In this study it was confirmed that drinking hydrogen water caused hydrogen from the stomach to be delivered to the blood in 3 minutes, and that it reduced the level of oxidative stress. Molecular Hydrogen functionally and morphologically protects the kidney against cisplatin-induced toxicity without impairing its anti-tumor activity.

Hyperbaric hydrogen therapy: a possible treatment for cancer in mice
One of the oldest studies on molecular hydrogen, published in 1975. Mice with tumors who were exposed to hydrogen therapy had (i) tumors that turned black (ii) tumors that had shrunk at their base and seemed to be in the process of being “Pinched off”. Continuous exposure to hyperbaric hydrogen chamber caused remission of the multiple squamous cell carcinomas. Even in this initial study, the scientists who conducted the research theorized that hydrogen may scavenge the •OH radical by means of the exothermic reaction: H2 + •OH –> H2O + H•. It’s also interesting to note that it was proposed in this article that the remaining H• could effectively scavenge superoxide radicals (O2- to form OH2-)
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