Liver Functions

Molecular Hydrogen Research on Liver Functions

Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation
Mice were infected with the parasite Schistosoma mansoni, which causes inflammation in the liver. Then half the mice were placed in a 50L hyperbaric chamber in normal atmospheric pressures supplemented with 0.7 MPa of Molecular Hydrogen gas. Mice treated with hyperbaric molecular hydrogen were in much better shape. For example, liver fibrosis caused by oxidative stress was down by 60% in mice treated with molecular hydrogen.

Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis
Molecular Hydrogen is released by bacteria in the intestines during carbohydrate fermentation. This study examined if internally produced molecular hydrogen could increase the host’s resistance to oxidative and inflammatory stresses. Mice were treated with or without antibiotics for 3 days. These mice were then tested for molecular hydrogen concentrations. Mice that were not treated with antibiotics had highest molecular hydrogen concentrations in the cecum (beginning of large intestine) followed by the small intestine, large intestine, liver, spleen, and blood. There was also trace levels of molecular hydrogen detected in the brain. Mice treated with mice had significantly reduced levels of molecular hydrogen in all organs tested. The study went further to determine if supplementation of molecular hydrogen infused water could help the antibiotic treated mice fight off inflammatory and oxidative stresses as well as mice with normal gut bacteria. As expected, mice supplemented with H2 water had decreased inflammatory markers (ALT and AST). The significant finding in this study was that the anti-inflammatory effect of molecular hydrogen supplemented via water was greater than anti-inflammatory effect of the molecular hydrogen released from gut bacteria.

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress
Malondialdehyde (MDA) is a widely used indicator for free radical-mediated lipid peroxidation. Hepatic injury was measured by recording the MDA levels in liver tissues. Hepatic tissue injury was induced in the mice by ischemia, causing Reactive Oxygen Species (ROS) to form in the liver of the mice. Mice receiving 4% Hydrogen gas for their anesthetic gas had almost 0% damage to their livers caused by ROS.
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